The grand finale of the Human Microbiome Action project took place in February 29th, 2024, in the heart of Brussels. Over the past three years, Human Microbiome Action has been at the forefront of groundbreaking research and innovation, aiming to address the global challenge of chronic diseases through a deeper understanding of the human microbiome. Spanning various fields, the project has united researchers in a collaborative effort to shape the future of microbiome research.