Scientific Article
Sympathetic nervous activation, mitochondrial dysfunction and outcome in acutely decompensated cirrhosis: the metabolomic prognostic models (CLIF-C MET)
Current prognostic scores of patients with acutely decompensated cirrhosis (AD), particularly those with acute-on-chronic liver failure (ACLF), underestimate the risk of mortality. This is probably because systemic inflammation (SI), the major driver of AD/ACLF, is not reflected in the scores. SI induces metabolic changes, which impair delivery of the necessary energy for the immune reaction. This investigation aimed to identify metabolites associated with short-term (28-day) death and to design metabolomic prognostic models.
Weiss, E., de la Peña-Ramirez, C., Aguilar, F., Lozano, J.J., Sánchez-Garrido, C., Sierra, P., Martin, P.I., Diaz, J.M., Fenaille, F., Castelli, F.A., Gustot, T., Laleman, W., Albillos, A., Alessandria, C., Domenicali, M., Caraceni, P., Piano, S., Saliba, F., Zeuzem, S., Gerbes, A.L., Wendon, J.A., Jansen, C., Gu, W., Papp, M., Mookerjee, R., Gambino, C.G., Jiménez, C., Giovo, I., Zaccherini, G., Merli, M., Putignano, A., Uschner, F.E., Berg, T., Bruns, T., Trautwein, C., Zipprich, A., Bañares, R., Presa, J., Genesca, J., Vargas, V., Fernández, J., Bernardi, M., Angeli, P., Jalan, R., Claria, J., Junot, C., Moreau, R., Trebicka, J., Arroyo, V. Sympathetic nervous activation, mitochondrial dysfunction and outcome in acutely decompensated cirrhosis: the metabolomic prognostic models (CLIF-C MET). Gut. 2023 Aug;72(8):1581-1591. doi: 10.1136/gutjnl-2022-328708. Epub 2023 Feb 14. Erratum in: Gut. 2023 Nov;72(11). doi: 10.1136/gutjnl-2022-328708corr1. PMID: 36788015; PMCID: PMC10359524.
