The European Foundation for the Study of Chronic Liver Failure (EF CLIF) was created with the aim of designing, promoting and supporting studies on the mechanism, prevention and treatment of liver cirrhosis and its complications; particularly, acute-on-chronic liver failure. EF CLIF is a non-profit organization committed to fight against a disease that represents the seventh most common cause of death in Western Europe. In the origin of the EF CLIF lies the European Association for the Study of the Liver – Chronic Liver Failure (EASL-CLIF) Consortium. An independent entity, the Consortium, with 106 hospitals in 26 countries is an important instrument for carrying out observational and therapeutic studies on large series of patients. Since its foundation (2009), the EASL-CLIF consortium’s most significant achievement has been in identifying, characterizing, establishing diagnostic criteria, designing new prognostic scoring, and understanding the mechanisms of a new syndrome (Acute-on-Chronic Liver Failure, ACLF), which constitutes the principal cause of death from cirrhosis.