The EBRIS Foundation’s mission is to serve as a unique multidisciplinary research hub focused on using cutting edge technologies to understand the molecular basis of human diseases in order to translate basic discoveries made in the laboratory into novel therapeutic and preventive interventions, new models of human disease, pioneering therapies, and drug delivery systems that can benefit patients with various diseases. The objective of the EBRIS Foundation is to network with other European research groups to create a top-level research network through the development of projects focused on the interplay between host and environment. Clinical models such as celiac disease, type 1 diabetes, autism and schizophrenia are thoroughly investigated to determine how environmental factors, especially during the first years of life, influence the microbiome, some specific metabolic patterns, and the mechanisms that govern the switch between tolerance and immunity in autoimmune diseases. The EBRIS Foundation has already established a network of European research institutes starting from pre-existing interactions coordinated by the Massachusetts General Hospital of the Harvard Medical School. In addition, the Foundation can rely on a local and national network of medical institutions, universities and health companies.