Scientific Article
Genetic variation in TERT modifies the risk of hepatocellular carcinoma in alcohol-related cirrhosis: results from a genome-wide case-control study
Hepatocellular carcinoma (HCC) often develops in patients with alcohol-related cirrhosis at an annual risk of up to 2.5%. Some host genetic risk factors have been identified but do not account for the majority of the variance in occurrence. This study aimed to identify novel susceptibility loci for the development of HCC in people with alcohol related cirrhosis.
Buch, S., Innes, H., Lutz, P.L., Nischalke, H.D., Marquardt, J.U., Fischer, J., Weiss, K.H., Rosendahl, J., Marot, A., Krawczyk, M., Casper, M., Lammert, F., Eyer, F., Vogel, A., Marhenke, S., von Felden, J., Sharma, R., Atkinson, S.R., McQuillin, A., Nattermann, J., Schafmayer, C., Franke, A., Strassburg, C., Rietschel, M., Altmann, H., Sulk, S., Thangapandi, V.R., Brosch, M., Lackner, C., Stauber, R.E., Canbay, A., Link, A., Reiberger, T., Mandorfer, M., Semmler, G., Scheiner, B., Datz, C., Romeo, S., Ginanni Corradini, S., Irving, W.L., Morling, J.R., Guha, I.N., Barnes, E., Ansari, M.A., Quistrebert, J., Valenti, L., Müller, S.A., Morgan, M.Y., Dufour, J.F., Trebicka, J., Berg, T., Deltenre, P., Mueller, S., Hampe, J., Stickel, F. Genetic variation in TERT modifies the risk of hepatocellular carcinoma in alcohol-related cirrhosis: results from a genome-wide case-control study. Gut. 2023 Feb;72(2):381-391. doi: 10.1136/gutjnl-2022-327196. Epub 2022 Jul 4. PMID: 35788059; PMCID: PMC9872243.
